Hi All,
I have been thru my 4th miscarriage in a row. Im 29yrs old and this journey to have our own baby has been truly brutal.
The first 2 m/cs were not tested and we did not have a proper embryo. They were sort of blighted ovum pregnancies. Then we started seeing a RE and she ran prelimanary tests and nuthing came up. So she started me on prometrium 100mg BID(total of 200mg/day) from 7dpo(CD-27 in my case as I ovulate late) and baby aspirin. I got pregnant naturally on the first try and we saw the heartbeat at 6.5 weeks and lost it when we went for our follow-up sonogram at 7.5 weeks. Had a D&C and got the fetal tissue karyotyped. We found that we actually would have had a normal boy( 46XY) chromosomes.
Fast forward to after the 3rd miscarriage, we saw another RE at shadygrove, MD for further evaluation and he recomended that we up the promterium to 200mg X 2 times a day and start the promterium 3dpo instead of 7dpo and stay on the baby aspirin. Also we met with a leading perinatologist and he recomended that we add lovenox-80mg once per day to the mix of meds. So we once again got pregnant on our own and the peri started the lovenox about 18dpo but had me take 40mg untill 7.5 weeks when we saw 2 very strong heartbeats of identical twins. We knew very early on that we are having identical twins coz we were being closely monitored by the RE right from 13dpo when we got a positive HPT. So from 7.5 week onwards I was on 80mg of lovenox once a day. I had severe nausea and was vommiting like crazy so I was also on zofram from the 7th week onwards. Once again at our 9 week sonogram we saw 2 very strong beating hearts( 167bpm & 170 bpm) and we found out that we are having monochorionic-diamniotic identicals(coz we found the diving membrane) and we were relieved. Then at our NT scan apt at 12w2d we were devasted beyond belief to find that we lost both our twins 
( They stopped growing on the very same day(i.e., 11w) so we were once again scheduled for a D&C. Our peri gave us the same **** that it would most likely be a chromosomal issue , lets wait for the fetal karyotyping result and go from there. Just yesterday we recieved the result and as I had predicted to my peri they turned out to be very healthy & normal babies. We found out they were boys(46XY) ...It was so so sad to know that 2 more normal babies got wasted for no reason whatsoever inspite of us doing whatever was in our hands and being compliant.
I have been thru the thrombophillic panel tests which included all the factor leidens, protein S & C , anti-thyroid , ANA and anti cardiolipin antibodies. Every single thing has come back to be normal including DH & my own karyotyping result. My peri had put me on the lovenox coz he said it does not hurt/maybe I have some clotting disorder that has not yet been studied. But all of this did not work. Now the only thing I have not delved into is Immune testing. I have not had my APA or the other immune related stuff tested yet and was wondering if that would help. I recently had my ANA tested and I was on baby aspirin and fish oil at the time. The ANA came borderline like th upper normal limit was 99 and mine was 100 so my RE said lets just ignore that coz 100 is most likely normal. I mean im beginning to wonder would my ANA be higher if i was NOT on the BABY ASPIRIN at the time and so should I repeat it. Should I seek the immune testing or what should I do. I really do not mind trying the immune testing but is it worth it? Has anybody had a success story after going thru something like this?
All of this is absolutely soul destroying and frustrating not knowing what is going on when all of my test results are normal as well all my angels lost in the process have also been normal.
Any information or personal experience is more than welcome and I'll be grateful for all the info shared.